I. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Nutr Clin Pract. . iron sucrose increases levels of calcium chloride by enhancing GI absorption. Applies only to oral form of both agents. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Accessed: 4/12/2011. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Individual plans may vary Applies only to oral form of both agents. 1 Dosing for patients who weigh less than 50 kg Maximum recommended single dose: 300 mg (See Prescriber's Orders). Oral and parenteral products - see background option for oral products. Use Caution/Monitor. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Avoid or Use Alternate Drug. . A healthcare provider will give you this injection. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Drug Des Devel Ther; 5: 5160. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Applies only to oral form of both agents. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Separate by 2 hr. Applies only to oral form of both agents. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Applies only to oral form of both agents. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Either increases effects of the other by pharmacodynamic synergism. Official Journal of the International Society of Nephrology. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Use Caution/Monitor. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Minor/Significance Unknown. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. and formulary information changes. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. 1) Ganzoni AM. Applies only to oral form of both agents. Deferasirox chelates iron. Applies only to oral form of both agents. Applies only to oral form of both agents. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Slowing the infusion rate may alleviate symptoms. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Avoid or Use Alternate Drug. Separate dosing of tetracyclines from these products. Minor/Significance Unknown. DICP. 4. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Applies only to oral form of both agents. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Otherwise, call a poison control center right away. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Applies only to oral form of both agents. This may be helped by giving the medication more slowly or at a lower dose. David McAuley, Pharm.D. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Applies only to oral form of both agents. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. 1000 mg. 20 MINUTES. Minor/Significance Unknown. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Do not administer Venofer to patients with evidence of iron overload. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Avoid or Use Alternate Drug. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Due Date form Ultrasound Report. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Always ask your health care professional for complete information about this product and your specific health needs. Applies only to oral form of both agents. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. (3) Known hypersensitivity to Venofer. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. 2. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. The dosage of Venofer is expressed in mg of elemental iron. Use Caution/Monitor. Parenteral iron dextran therapy: a review. Avoid or Use Alternate Drug. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). Applies only to oral form of both agents. ONE DOSE. Either increases effects of the other by pharmacodynamic synergism. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Reactions have occurred following the first dose or subsequent doses of Venofer. The recipient will receive more details and instructions to access this offer. Applies only to oral form of both agents. Access your plan list on any device mobile or desktop. View the formulary and any restrictions for each plan. Use Caution/Monitor. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. This drug is available at a higher level co-pay. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Interaction only with oral iron administration. Venofer may reduce the absorption of concomitantly administered oral iron preparations. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Applies only to oral form of both agents. Dosing Administration & Considerations . Venofer must only be administered intravenously either by slow injection or by infusion. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Am J Hosp Pharm. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Minor (1)iron sucrose, captopril. Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Do not double the dose to catch up. Use Caution/Monitor. Separate by at least 4 hours. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. *Repeat dose if iron deficiency anemia reoccurs. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Copyright 1993-2021 Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Diagnosis and management of iron deficiency anaemia: a clinical update. Avoid or Use Alternate Drug. Information last revised December 2022. Your doctor will do laboratory tests to monitor your response. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. Learn how to store and discard medical supplies safely. If we don't have the calculator you need we'll try to make it for you and add it to the website. Use Caution/Monitor. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. 1. Applies only to oral form of both agents. Corrected Sodium and Effective Osmolality. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. No data are available regarding overdosage of Venofer in humans. Minor/Significance Unknown. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Observed Hb = the patients current hemoglobin in g/dl. Venofer is given as an infusion into a vein. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Contraindicated. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Included in the iron dextran package insert. There are physiological variation in iron reserves such as the decrease during menstruation period. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Nutrition. Administer on 5 different occasions over a 14 day period. Modify Therapy/Monitor Closely. Use Caution/Monitor. Dosage form: injection, solution The dosage of Venofer is expressed in mg of elemental iron. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Applies only to oral form of both agents. 2010; 193(9):525-32. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Use Caution/Monitor. Separate dosing of tetracyclines from these products. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. All Rights Reserved. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Reference www.medicines.org.uk Background Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. 2015: 763576. A: Generally acceptable. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Avoid or Use Alternate Drug. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Use Caution/Monitor. This site contains information for licensed healthcare professionals in the United States. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Applies only to oral form of both agents. Iron deficiency anemia is the type of anemia caused by iron depletion. Avoid or Use Alternate Drug. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Dosing: (a) Divide calculated total cumulate dose . Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I.
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